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Prostate small cell carcinoma

MedGen UID:
266251
•Concept ID:
C1300585
•
Neoplastic Process
Synonyms: Oat cell carcinoma of prostate; Oat cell carcinoma of the prostate; prostate gland small cell carcinoma; prostate Oat cell carcinoma; prostate oat cell carcinoma; prostate small cell carcinoma; prostate small cell NEC; prostate small cell neuroendocrine carcinoma; PRSCC; Small cell carcinoma of prostate; small cell carcinoma of prostate; small cell carcinoma of prostate gland; small cell carcinoma of the prostate
SNOMED CT: Small cell carcinoma of prostate (396198006)
 
Monarch Initiative: MONDO:0006390

Definition

A neuroendocrine carcinoma of the prostate gland with unfavorable prognosis, composed of small cells containing neurosecretory granules. Approximately half of the cases show a mixture of small cells and adenocarcinoma cells. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate small cell carcinoma

Professional guidelines

PubMed

Intracranial Metastases from Prostate Carcinoma: Classification, Management, and Prognostication.
Ganau M, Gallinaro P, Cebula H, Scibilia A, Todeschi J, Gubian A, Nannavecchia B, Signorelli F, Pop R, Coca HA, Proust F, Chibbaro S
World Neurosurg 2020 Feb;134:e559-e565. Epub 2019 Oct 31 doi: 10.1016/j.wneu.2019.10.125. PMID: 31678450
The Role of Next-Generation Sequencing in Castration-Resistant Prostate Cancer Treatment.
Hovelson DH, Tomlins SA
Cancer J 2016 Sep/Oct;22(5):357-361. doi: 10.1097/PPO.0000000000000217. PMID: 27749331Free PMC Article
Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective.
Monn MF, Cheng L
Expert Rev Anticancer Ther 2016 Oct;16(10):1029-37. Epub 2016 Aug 26 doi: 10.1080/14737140.2016.1226137. PMID: 27534689

Recent clinical studies

Etiology

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation.
Quintanal-Villalonga A, Kawasaki K, Redin E, Uddin F, Rakhade S, Durani V, Sabet A, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Kinyua D, Zhong H, Mello BP, Ciampricotti M, Bhanot UK, Linkov I, Qiu J, Patel RA, Morrissey C, Mehta S, Barnes J, Haffner MC, Socci ND, Koche RP, de Stanchina E, Molina-Pinelo S, Salehi S, Yu HA, Chan JM, Rudin CM
Signal Transduct Target Ther 2024 Jul 26;9(1):189. doi: 10.1038/s41392-024-01908-y. PMID: 39054323Free PMC Article
Clinical performance of a novel chemiluminescent enzyme immunoassay for FGF23.
Ito N, Kubota T, Kitanaka S, Fujiwara I, Adachi M, Takeuchi Y, Yamagami H, Kimura T, Shinoda T, Minagawa M, Okazaki R, Ozono K, Seino Y, Fukumoto S
J Bone Miner Metab 2021 Nov;39(6):1066-1075. Epub 2021 Jul 13 doi: 10.1007/s00774-021-01250-1. PMID: 34255195

Diagnosis

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation.
Quintanal-Villalonga A, Kawasaki K, Redin E, Uddin F, Rakhade S, Durani V, Sabet A, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Kinyua D, Zhong H, Mello BP, Ciampricotti M, Bhanot UK, Linkov I, Qiu J, Patel RA, Morrissey C, Mehta S, Barnes J, Haffner MC, Socci ND, Koche RP, de Stanchina E, Molina-Pinelo S, Salehi S, Yu HA, Chan JM, Rudin CM
Signal Transduct Target Ther 2024 Jul 26;9(1):189. doi: 10.1038/s41392-024-01908-y. PMID: 39054323Free PMC Article
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM
Sci Transl Med 2023 Aug 2;15(707):eadf7006. doi: 10.1126/scitranslmed.adf7006. PMID: 37531417Free PMC Article
Clinical performance of a novel chemiluminescent enzyme immunoassay for FGF23.
Ito N, Kubota T, Kitanaka S, Fujiwara I, Adachi M, Takeuchi Y, Yamagami H, Kimura T, Shinoda T, Minagawa M, Okazaki R, Ozono K, Seino Y, Fukumoto S
J Bone Miner Metab 2021 Nov;39(6):1066-1075. Epub 2021 Jul 13 doi: 10.1007/s00774-021-01250-1. PMID: 34255195
Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective.
Monn MF, Cheng L
Expert Rev Anticancer Ther 2016 Oct;16(10):1029-37. Epub 2016 Aug 26 doi: 10.1080/14737140.2016.1226137. PMID: 27534689
Genitourinary small cell malignancies: prostate and bladder.
Shatagopam K, Kaimakliotis HZ, Cheng L, Koch MO
Future Oncol 2015;11(3):479-88. doi: 10.2217/fon.14.277. PMID: 25675127

Therapy

Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective.
Monn MF, Cheng L
Expert Rev Anticancer Ther 2016 Oct;16(10):1029-37. Epub 2016 Aug 26 doi: 10.1080/14737140.2016.1226137. PMID: 27534689
Prostate small cell carcinoma and skin metastases: a rare entity.
Yildirim Y, Akcay Y, Ozyilkan O, Celasun B
Med Princ Pract 2008;17(3):250-2. Epub 2008 Apr 10 doi: 10.1159/000117801. PMID: 18408396
Molecular characterization of prostatic small-cell neuroendocrine carcinoma.
Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS
Prostate 2003 Apr 1;55(1):55-64. doi: 10.1002/pros.10217. PMID: 12640661

Prognosis

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation.
Quintanal-Villalonga A, Kawasaki K, Redin E, Uddin F, Rakhade S, Durani V, Sabet A, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Kinyua D, Zhong H, Mello BP, Ciampricotti M, Bhanot UK, Linkov I, Qiu J, Patel RA, Morrissey C, Mehta S, Barnes J, Haffner MC, Socci ND, Koche RP, de Stanchina E, Molina-Pinelo S, Salehi S, Yu HA, Chan JM, Rudin CM
Signal Transduct Target Ther 2024 Jul 26;9(1):189. doi: 10.1038/s41392-024-01908-y. PMID: 39054323Free PMC Article
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM
Sci Transl Med 2023 Aug 2;15(707):eadf7006. doi: 10.1126/scitranslmed.adf7006. PMID: 37531417Free PMC Article
Current trend of worsening prognosis of prostate small cell carcinoma: A population-based study.
Wang J, Liu X, Wang Y, Ren G
Cancer Med 2019 Nov;8(15):6799-6806. Epub 2019 Sep 13 doi: 10.1002/cam4.2551. PMID: 31518071Free PMC Article
Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective.
Monn MF, Cheng L
Expert Rev Anticancer Ther 2016 Oct;16(10):1029-37. Epub 2016 Aug 26 doi: 10.1080/14737140.2016.1226137. PMID: 27534689
Genitourinary small cell malignancies: prostate and bladder.
Shatagopam K, Kaimakliotis HZ, Cheng L, Koch MO
Future Oncol 2015;11(3):479-88. doi: 10.2217/fon.14.277. PMID: 25675127

Clinical prediction guides

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation.
Quintanal-Villalonga A, Kawasaki K, Redin E, Uddin F, Rakhade S, Durani V, Sabet A, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Kinyua D, Zhong H, Mello BP, Ciampricotti M, Bhanot UK, Linkov I, Qiu J, Patel RA, Morrissey C, Mehta S, Barnes J, Haffner MC, Socci ND, Koche RP, de Stanchina E, Molina-Pinelo S, Salehi S, Yu HA, Chan JM, Rudin CM
Signal Transduct Target Ther 2024 Jul 26;9(1):189. doi: 10.1038/s41392-024-01908-y. PMID: 39054323Free PMC Article
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM
Sci Transl Med 2023 Aug 2;15(707):eadf7006. doi: 10.1126/scitranslmed.adf7006. PMID: 37531417Free PMC Article
Current trend of worsening prognosis of prostate small cell carcinoma: A population-based study.
Wang J, Liu X, Wang Y, Ren G
Cancer Med 2019 Nov;8(15):6799-6806. Epub 2019 Sep 13 doi: 10.1002/cam4.2551. PMID: 31518071Free PMC Article
Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective.
Monn MF, Cheng L
Expert Rev Anticancer Ther 2016 Oct;16(10):1029-37. Epub 2016 Aug 26 doi: 10.1080/14737140.2016.1226137. PMID: 27534689
Prostate small cell carcinoma and skin metastases: a rare entity.
Yildirim Y, Akcay Y, Ozyilkan O, Celasun B
Med Princ Pract 2008;17(3):250-2. Epub 2008 Apr 10 doi: 10.1159/000117801. PMID: 18408396

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